Recently Approved Research Projects
by Kaiser Permanente Research Team, Elizabeth McGlynn, Executive Director
The Impact of COVID-19 on physical, mental, and social health outcomes; Genome-wide study of bloodstream infection; Statin treatment and incident Alzheimer's disease and related dementias; Molecular markers of severe mental illness; Characterization of the Shared Genetic Basis of Dementia Cancer; The association of e-cigerette use and health care utilization, cardiovascular disease, pulmonary outcomes, and COVID-19.
Memory Loss: What is Normal Aging?
by Neurologist Sharon Sha, MD, MS, Clinical Assistant Professor
Department of Neurology and Neurological Sciences, Stanford University School of Medicine
Is this Normal Aging? Is this Dementia? Is this Alzheimer's? These terms are defined along with the progression of Normal Aging to Mild Cognitive Impairment, to Dementia.
Rice University Engineers Use Gene Editing to
Facilitate Drug Discovery
by Xue Sherry Gao, Rice's Brown School of Engineering.
A five-year National Institutes of Health grant will allow the lab of biomolecular engineer Xue Sherry Gao to use advanced gene-editing technology to help discover new drugs that stay one step ahead of diseases' frustrating ability to become resistant.
Stanford Study Reveals Immunological Deviations and Lapses in Severe COVID-19 Cases
by Bali Pulendran, PhD, professor of pathology and of microbiology and immunology and the senior author of the study.
Some people get really sick from COVID-19, and others don’t. Now, a study by investigators at the Stanford University of Medicine and other institutions has turned up immunological deviations and lapses that appear to spell the difference between severe and mild cases of COVID-19.
Study Shows Link Between High Blood Lead Levels and Aberrant Methylation DNA
by Dr. Yared B. Yohannes, Hokkaido University
Scientists have unveiled a correlation between high blood lead levels in children and methylation of genes involved in haem synthesis and carcinogenesis, indicating a previously unknown mechanism for lead poisoning.
Immunothrombtic Dysregulation is a Key Factor in Disease Severity in COVID-19
by Konstantin Stark, Clinician, Ludwig Maximilian University of Munich
In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies.
Launching a Rapid Test for COVID
by Prof Zhanfeng Cui is the Donald Pollock Professor of Chemical Engineering, Department of Engineering Science, and Director of Tissue Engineering and Bioprocessing, Institute of Biomedical Engineering, University of Oxford.
Professor Zhanfeng Cui speaks to News-Medical about his research into COVID-19, and how he developed a rapid COVID-19 test.
Researchers Develop a Deep Learning-based Algorithm for Predicting Sites of DNA Methylation
by Hakon Hakonarson, MD, PhD, Director of the Center for Applied Genomics (CAG) at CHOP and one of the senior co-authors of the study
A team of researchers from New Jersey Institute of Technology and Children's Hospital of Philadelphia have developed an algorithm through machine learning that helps predict sites of DNA methylation - a process that can change the activity of DNA without changing its overall structure - and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.
Study: Inhibition of TLK Protein Stimulates the Innate Immune System
by Travis H. Stracker, Researcher, Institute for Research in Biomedicine
Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona's Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a very important factor in the response to cancer.
Normal DNA Repair Process Can Lead to Mutations in Cancer
by Fran Supek, ICREA Researcher, Institute for Research in Biomedicine
Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer. Surprisingly, the scientists have also identified that the newly discovered hypermutation type is related to a normal DNA repair process.
A New Method to Diagnose Brain Tumors Without Any Incisions
by Chris Pacia, third-year doctoral student in biomedical engineering and first author of the study
Brain tumors are typically diagnosed using MRI imaging, as taking a sample for a tissue biopsy is risky and may not be possible due to tumor location or a patient's poor health conditions.